Dresden 2026 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 46: Poster II
CPP 46.20: Poster
Donnerstag, 12. März 2026, 09:30–11:30, P5
Diffusion and stiffness characterization of photocrosslinked hydrogels to replicate biological tissues — •Lena Hilf1, Dimitris Missirlis1, 2, and Kai Melde1 — 1Institute for Molecular Systems Engineering and Advanced Materials, Universität Heidelberg — 2MPI for Medical Research, Heidelberg
Microphysiological systems (MPS), such as organs-on-a-chip, aiming to replicate the spatial arrangement of biological tissues found in vivo are in need of a reliable and replicable way to recreate the biophysical environment including topography and mechanical properties. One possible route is via selective photocrosslinking of hydrogel scaffolds, which can be performed in situ in microfluidic platforms.
However, we still lack reliable information about key properties of potential hydrogel candidates in these systems, which influence cell adhesion and spreading, as well as the uptake of media components.
In this work, we characterize the stiffness, mesh size and diffusion constant of a range of hydrogels created using photolithpgraphy. We employ both optical and mechanical approaches, taking into account the versatility of hydrogel responses to different measurement methods.
Our results together with cell proliferation assays allow for a more targeted choice of hydrogels to serve as artifical extracellular matrices in MPS.
Keywords: Hydrogel; Stiffness; Diffusion; Porosity; Mesh size