Dresden 2026 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 54: Gels, Polymer Networks and Elastomers II
CPP 54.4: Vortrag
Freitag, 13. März 2026, 10:30–10:45, ZEU/0255
Assembling a true Olympic gel from >16,000 combinatorial DNA rings — Sarah K. Speed1,2, Yu-Hsuan Peng1,2, Azra Atabay1,2, Krishna Gupta1,2, Toni Müller3,4, Carolin Fischer5, Ilka Hermes6, Jens-Uwe Sommer3,4,7, Michael Lang3, and •Elisha Krieg1,2 — 1Division of Polymer Biomaterials Science, Leibniz Institute of Polymer Research Dresden, Germany — 2Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, Germany — 3Division of the Theory of Polymers, Leibniz Institute of Polymer Research Dresden, Germany — 4Institute for Theoretical Physics, Technische Universität Dresden, Germany — 5B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, Germany — 6Division of Physical Chemistry and Physics of Polymers, Leibniz Institute of Polymer Research Dresden, Germany — 7Cluster of Excellence Physics of Life, Technische Universität Dresden, Germany
Olympic gels consist of a three-dimensional network of mechanically interlocked cyclic molecules providing unique mechanical properties. We report the successful assembly of a true Olympic gel from a library of DNA rings comprising more than 16,000 distinct molecules. Each of these rings contains a unique sequence domain that can be enzymatically activated to produce reactive termini that favor intramolecular cyclization. Results are shown on the genetic, mechanical, and structural characteristics of the material by next-generation sequencing, oscillatory rheology, large-scale computational simulations, atomic force microscopy, and cryogenic electron microscopy.
Keywords: DNA; rheology; elasticity; self-assembly; simulations