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DY: Fachverband Dynamik und Statistische Physik
DY 57: Statistical Physics of Biological Systems IV (joint session BP/DY)
DY 57.6: Vortrag
Freitag, 13. März 2026, 11:15–11:30, BAR/SCHÖ
Understanding Influenza A Virus particles detaching from reconstructed cell surfaces — •Thomas Kolbe1,2, Pierre Gaspard1, and Bortolo Matteo Mognetti1,2 — 1CENOLI, Université Libre de Bruxelles (ULB) — 2IB2 - Interuniversity Institute of Bioinformatics in Brussels
Influenza infection is a multistage process that involves the trafficking of viral particles across the cell membrane. Before endocytosis, virions target the membrane by binding hemagglutinin ligands to sialic acid residues on cell receptors. After budding, neuraminidase cleaves these residues, enabling virions to detach from the infected cell surface.
We examine detachment dynamics through simulations and theoretical analysis. We explain experimental findings showing that the time required for virions to detach can decrease as the single-trajectory average number of bonds increases - a counterintuitive result specific to neuraminidase activity. Furthermore, we demonstrate that the detachment time is not governed by a Poisson distribution but depends on multiple factors, including ligand-receptor reaction rates, virion size, and receptor diffusion constant. These results clarify how biochemical parameters regulate the residence time of virions at the cell surface.
Keywords: Influenza A Virus; Virion Detachment; Neuraminidase Activity; Multivalent Interactions; Reaction-Diffusion Modeling