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HL: Fachverband Halbleiterphysik

HL 11: Focus Session: Quantum Emitters in 3D Semiconductors

HL 11.2: Hauptvortrag

Montag, 9. März 2026, 15:30–16:00, POT/0251

Diamond based quantum sensing for drug testing — •Romana Schirhagl — University Medical Center Groningen, Groningen, the Netherlands

Free radical generation plays a key role in the mechanisms of action of many different drugs. Additionally, free radical generation offers a powerful biomarker to quantify the drug efficacy. However, free radicals are difficult to measure since they are short lived and reactive. Diamond based quantum sensing offers a possible solution to this problem. We have demonstrated recently that we can predict which drugs might work in clinical samples. Here we can either measure stress responses [1] (as for instance caused by anti-cancer drugs or anti-biotics) or reduction of oxidative stress [2] (as caused by anti-inflammatory drugs, certain inhibitors or anti-oxidants). We tested synovial fluid from rheumatoid arthritis and osteoarthritis patients. We can clearly differentiate the two groups which differ in their responsiveness to Piroxicam. Such ex-vivo measurements can be used for diagnostic purposes, to predict the effectiveness of a drug or to elucidate its mechanism of action. In my talk I will show different examples of how quantum sensing can be used in drug development. 1 Tian, Y., Nusantara, A.C., Hamoh, T., Mzyk, A., Tian, X., Perona Martinez, F., Li, R., Permentier, H.P. and Schirhagl, R., 2022. ACS Applied Materials & Interfaces, 14(34), pp.39265-39273. 2 Sigaeva, A., Shirzad, H., Martinez, F.P., Nusantara, A.C., Mougios, N., Chipaux, M. and Schirhagl, R., 2022. Small, 18(44), p.2105750.