Dresden 2026 – wissenschaftliches Programm
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MA: Fachverband Magnetismus
MA 7: Poster Magnetism I
MA 7.76: Poster
Montag, 9. März 2026, 09:30–12:30, P2
Optimization of metal-doped M0.2Fe2.8O4/PEG nanocomposite for enhanced magnetic and relaxometric performance in MRI applications — •Mennatallah Abouhasswa1, Ahmed Al Shahawy2, Samaa El Dek2, Messaoud Harfouche3, Nagwa Okasha1, Giuliana Aquilanti4, Neama Imam5, and Jan Ingo Flege5 — 1Physics Department, Ain Shams University, Egypt — 2Faculty of Postgraduate Studies for Advanced Sciences, BeniSuef University, Egypt — 3SESAME Synchrotron, Jordan — 4Elettra,Sincrotrone Trieste, Italy — 5Brandenburg University of Technology Cottbus, Senftenberg, Germany
Magnetic spinel ferrites are promising magnetic resonance imaging (MRI) contrast agents owing to their tunable structure, magnetic anisotropy, and biocompatibility. M0.2Fe2.8O4 nanoparticles (M = Fe2+, Mn2+, Cu2+) coated Polyethylene glycol (30%PEG-6000) were synthesized to correlate cation substitution with structural, magnetic, and relaxometric behavior. XRD, HRTEM, FTIR, XPS, synchrotron-based XAFS spectroscopy, and Vibrating Sample Magnetometer (VSM) confirmed single-phase nanocrystals (8-13 nm) with mixed Fe2+/Fe3+ states and preserved spinel geometry upon PEG coating. Mn-doping enhanced saturation magnetization and transverse relaxivity, providing the strongest T2 weighted MRI contrast. The results demonstrate that combining controlled B-site substitution with hydrophilic PEG capping enables concurrent optimization of magnetic response and colloidal stability, highlighting Mn0.2Fe2.8O4/PEG as a high-performance and biocompatible MRI nanocontrast agent.
Keywords: magnetic nanoparticles; PEG coating; MRI contrast agent; XPS; XAFS