Erlangen 2026 – wissenschaftliches Programm

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ST: Fachverband Strahlen- und Medizinphysik

ST 1: Medical Imaging

ST 1.2: Vortrag

Dienstag, 17. März 2026, 11:15–11:30, KH 01.013

Clinical studies on the proton radiography system — •Sophia Wortmann, Patricia Borrego Jiménez, Kevin Kröninger, Hendrik Speiser, Helen Thews, and Jens Weingarten — TU Dortmund Department of Physics, Dortmund, Germany

In proton radiography the water-equivalent thickness (WET) is determined to characterize material and density distributions with high precision. In adaptive proton therapy this information can be used to detect range changes that arise from anatomical variations between treatment fractions. A two-plane imaging system (TPIS) was developed for this purpose and a corresponding simulation framework was created. The goal of this project is to validate the framework by comparing its results with calculations from the RayStation treatment-planning system and to prepare it for use in preclinical studies.

In this work the experimental measurements with the TPIS are reproduced in TOPAS and WET reconstructions that allow quantitative comparison are generated. The validation starts with simple PLA plate phantoms and is later extended to a more complex skull phantom. For all phantoms the achievable spatial resolution, the WET accuracy and the deposited dose are evaluated. These results provide an initial evaluation of the imaging performance of the system and are intended to support its use in future preclinical proton radiography studies.

Keywords: Adaptive proton therapy; Proton imaging; Simulation framework; WET measurements