Dresden 2003 – wissenschaftliches Programm
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CPP: Chemische Physik und Polymerphysik
CPP 21: POSTER B
CPP 21.13: Poster
Dienstag, 25. März 2003, 19:00–21:00, ZEU/250
The role of plasma membrane calcium pump stimulation by Calmodulin in neuronal calcium dynamics — •Michael Graupner — Institut für Theoretische Physik, Technische Universität Dresden
The plasma membrane calcium (PMCA) pump and the Na+/Ca2+ exchanger are the major means of Ca2+ extrusion at the presynaptic nerve terminal. The stimulation of the PMCA protein by the Ca42+/Calmodulin complex ranges on a time scale of minutes and enables the pump to display a memory to previous calcium transients. The role of this memory effect for the long-term behaviour of intracellular calcium dynamics is discussed by developing and implementing a theoretical model of the PMCA pump stimulation. Furthermore its relation to the inactivation of high-voltage directed calcium channels is evaluated.