Dresden 2003 – wissenschaftliches Programm
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CPP: Chemische Physik und Polymerphysik
CPP 21: POSTER B
CPP 21.18: Poster
Dienstag, 25. März 2003, 19:00–21:00, ZEU/250
Interface Rheology of Glycocalix Models: Impacts of carbohydrate conformation and subphase conditions — •Motomu Tanaka1, Stefan Schiefer1, Matthias Schneider1, and Gerald Fuller2 — 1Biophysik E22, TU Muenchen — 2Chem. Eng. Dept., Stanford Univ.
Cell surface glycocalix is made of oligo- and poly-saccharide chains of glycolipids, glycoproteins, and of trans-membrane proteoglycans. For example, glycolipids in animal cells are localized in the outer leaflet of the lipid bilayer and stabilize the structure of plasma membranes by a combination of various physical forces (e.g. electrostatic interaction, van der Waals force, and hydrogen bonding), which enables the carbohydrate to take a distinct conformation and interact with counter-part lectins and cell adhesion receptors. As a simplified physical model, viscoelastic properties of synthetic glycolipid monolayers was studied by an interfacial stress rheometer (ISR). The ISR device allows for highly sensitive and real-time measurements of viscoelastic parameters at different frequencies under controlled thermodynamic conditions (surface pressure, temperature). In this study, the impacts of two parameters on the interface rheology were studied: (a) head group conformation, and (b) subphase condition.