Regensburg 2004 – wissenschaftliches Programm

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SYLS: Life Sciences on the Nanometer Scale - Physics Meets Biology

SYLS 3: Symposium "Life Sciences on the Nanometer Scale - Physics Meets Biology"

SYLS 3.3: Poster

Mittwoch, 10. März 2004, 16:00–18:30, B

Interactions of Thionin with DNA-Strands: Intercalation vs External Stacking — •Christoph Hecht¹, Josef Friedrich¹, and Ta-Chau Chang² — ¹TU München, Physik-Department E14, Lehrstuhl für Physik Weihenstephan, 85350 Freising — ²Institute of Atomic and Molecular Science, Academia Sinica, Taiwan

The interaction of dye-molecules with DNA-strands plays an important role in anti-cancer drug research. We investigated the binding modes of thionin with various structures of short stranded DNA-molecules by measuring the response of a spectral hole to pressure variations. Thionin binds through Coulomb-interaction via external stacking to DNA-quadruplex structures. The binding to DNA-duplex structures, however, is different: One of the two possible isomers of thionin intercalates into the DNA-strands.