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HL: Halbleiterphysik

HL 48: Symposium: Bio- and Neurotransistors

HL 48.3: Talk

Tuesday, March 8, 2005, 11:45–12:15, TU P270

Detecting DNA Hybridization by a Microfabricated Field-effect Sensor — •Jürgen Fritz — MIT Media Laboratory, 20 Ames Street, Cambridge, MA 02139, USA. — present adress: International University Bremen, Campus Ring 1, 28759 Bremen, Germany

Detecting the presence and activity of biomolecules by electronic means is of growing interest due to its potential to simplify and miniaturize biosensors or medical devices. Label-free electronic detection of biomolecules with a microfabricated device offers the advantage of online-monitoring of biological samples and processes, and miniaturization and parallelization of sensors into arrays by using standard microfabrication techniques. One route to achieve electronic detection of biomolecules is to detect the intrinsic molecular charge of biomolecules by a field-effect device. Here we report on a microfabricated field-effect sensor which detects the binding of short DNA molecules to its sensor surface 1. We show functionalization strategies for such a sensor, and concentration dependence and specificity of the sensor signal. We summarize field-effect detection of biomolecules, show its promises, limits, and future applications.