Dresden 2006 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 20: Nano-Biomaterials and Devices

AKB 20.3: Vortrag

Donnerstag, 30. März 2006, 10:45–11:00, ZEU 255

DNA-switchable hybrid structures — •Andreas Reuter, Michael Olapinski, Tim Liedl, and Friedrich Simmel — Department für Physik, Ludwig-Maximilians-Universität München, Geschwister-Scholl-Platz 1, 80539 München

Programmable self-assembly with DNA molecules has been previously used for the construction of a variety of nanoscale structures as well as for the realization of simple machine-like molecular devices. These devices were capable of performing nanoscale movements such as stretching, rotation and even translocation. In combination with functional nucleic acids such as aptamers or ribozymes, functional DNA devices could be realized which can bind or release molecules, compute and respond autonomously to environmental inputs. We here demonstrate that also hybrid devices can be realized which are composed of an inorganic part such as a nanoparticle or a microstrucured electrode on a surface and a DNA actuating component. The DNA actuator part can be used to reversibly and selectively change the distance between organic components of the hybrid devices (such as fluorescent dyes) and the inorganic components. The conformational changes can be characterized by monitoring energy transfer between fluorophores and metallic device components. Such structures may find use in sensors and actuators where the transduction of a biomolecular recognition event to an electronic or optical signal is desired. On a more fundamental level, the ability to tailor and reversibly change the distance between nanoscale components can be used to study distance-dependent interaction phenomena between these components.