Dresden 2006 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 30: Poster Session I
AKB 30.7: Poster
Montag, 27. März 2006, 15:30–18:00, P1
Energy landscapes of model proteins — •Frank Dressel1,2, Sigismund Kobe2, and Michael Schroeder1 — 1Biotechnologisches Zentrum, TU Dresden, D-01062 Dresden — 2Institut fuer Theoretische Physik, TU Dresden, D-01062 Dresden
Proteins are molecular machines in living cells. Their functions are largely dependent on their spatial structure. Therefore, the knowledge of protein folding pathways and structural changes is important to understand possible malfunction as Alzheimer disease or mucoviscidosis. Despite of the huge complexity of the problem, a simple model for structure prediction can be applied [1] to investigate the exact low-lying energy landscape of proteins. The energy landscapes for some small proteins (e.g. Trp-cage (1L2Y) and Cecropin-Magainin hybrid (1D9J)) are presented. The ground state accessibility and the competition between ground state and metastable states are investigated and the relation to native states will be discussed.
[1]: F. Dressel, S. Kobe: No-dqGlobal optimization of proteins using a dynamical lattice modelNo-dq, arXiv:q-bio.BM/0412031