Dresden 2006 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 40: Poster Session II
AKB 40.11: Poster
Mittwoch, 29. März 2006, 16:30–19:30, P3
Prediction of site-specific amino acid distributions and limits of divergent evolutionary changes in protein sequences — •Markus Porto1, Ugo Bastolla2, H. Eduardo Roman3, and Michele Vendruscolo4 — 1Institut für Festkörperphysik, Technische Universität Darmstadt, Hochschulstr. 8, 64289 Darmstadt, Germany — 2Centro de Biología Molecular ‘Severo Ochoa’, Cantoblanco, 28049 Madrid, Spain — 3Dipartimento di Fisica, Università di Milano Bicocca, Piazza della Scienza 3, 20126 Milano, Italy — 4Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
We derive an analytic expression for site-specific stationary distributions of amino acids. The stationary distributions that we obtain have a Boltzmann-like shape, and their effective temperature parameter, measuring the limit of divergent evolutionary changes at a given site, can be predicted from a site-specific topological property. These analytic results, obtained without free parameters, are in very good agreement with the site-specific amino acid distributions obtained from the Protein Data Bank.
[1] M. Porto, H.E. Roman, M. Vendruscolo, and U. Bastolla, Mol. Biol. Evol. 22, 630 (2005); 1156 (2005).
[2] U. Bastolla, M. Porto, H.E. Roman, and M. Vendruscolo, Gene 347, 219 (2005).