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AKB: Biologische Physik

AKB 40: Poster Session II

AKB 40.42: Poster

Wednesday, March 29, 2006, 16:30–19:30, P3

Study of DNA/RNA strand interactions using lattice models — •Christian Simm, Sanjay Kumar, and Ralf Everaers — Max-Planck-Institut für Physik komplexer Systeme, Dresden

Research in binding properties of DNA/RNA is key for the understanding of many biological processes - like hairpin formation in ssDNA and miRNA, RNA secondary structure, and bubble formation during DNA transcription. We study lattice models of DNA which account for base stacking and polarity of the DNA strands. We draw comparisons to simpler models without these features to get a better understanding of the effects of stacking and polarity. We use exact enumeration and Monte-Carlo simulation techniques to test assumptions of the nearest-neighbour model.