Dresden 2006 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 40: Poster Session II

AKB 40.54: Poster

Mittwoch, 29. März 2006, 16:30–19:30, P3

Normal heart beat, alternans and fibrillation in a model for the rabbit ventricles — •Steffen Bauer , Georg Röder , and Markus Bär — Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin

Cardiac propagation is investigated by simulations of the modified Beeler-Reuter model using the geometry and muscle fibre orientation of the ventricles taken from the San Diego rabbit heart. Electrical excitation is introduced by a periodic pacing of the apex of the heart. Depending on the pacing frequency qualitatively different dynamics are observed namely normal heart beat, alternans and fibrillation at small, intermediate and large pacing frequencies, respectively. The simulated electric potential on the heart surface during normal heart beat agrees well with experimental data. The onset of alternans and fibrillation are in line with simulations of a one-dimensional model, where the corresponding instabilities are analyzed in more detail.