Dresden 2006 – wissenschaftliches Programm
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AKB: Biologische Physik
AKB 6: DNA Mechanics
AKB 6.1: Vortrag
Montag, 27. März 2006, 14:30–14:45, ZEU 260
Bubble Nucleation and Cooperativity in DNA Melting — •Saul Ares1, Nikolaos K. Voulgarakis2, Kim Ø. Rasmussen3, and Alan R. Bishop3 — 1Max-Planck-Institut für Physik komplexer Systeme, Nöthnitzer Str. 38, 01187 Dresden — 2Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA — 3Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
The onset of intermediate states (denaturation bubbles) and their role during the melting transition of DNA are studied using the Peyrard-Bishop-Dauxois model by Monte Carlo simulations with no adjustable parameters. Comparison is made with previously published experimental results that used a novel bubble quenching technique based in the possibility of hairpin formation on single strands of DNA. An excellent agreement is found between our theoretical predictions and experimental results. Melting curves, critical DNA segment length for stability of bubbles, and the possibility of a two-state transition are studied. The content of this contribution is published in Physical Review Letters 94, 035504 (2005).