Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 1: Cell Migration and Tissue Dynamics

BP 1.9: Vortrag

Montag, 25. Februar 2008, 12:15–12:30, C 243

Kinetics and scaling laws of growing cell populations — •Markus Radszuweit¹, Michael Block¹, Eckehard Schöll¹, and Dirk Drasdo² — ¹Institut f. Theo. Physik, Sekr. EW 7-1, Technische Universität Berlin, Hardenbergstr. 36, 10623 Berlin, Germany — ²INRIA, Rocquencourt, France

We study the growth kinetics and the critical surface dynamics of cell monolayers by a class of computationally efficient cellular automaton models avoiding lattice artifacts [1]. Our numerically derived front velocity relationship indicates the limitations of the Fisher-Kolmogorov-Petrovskii-Piskounov (FKPP) equation for tumor growth simulations. The critical surface dynamics corresponds to the Kardar-Parisi-Zhang (KPZ) universality class, which disagrees with the interpretation by Bru et al. [2] of their experimental observations as generic molecular-beam-epitaxy (MBE)-like growth. By comparison with a new cellular automaton for three-dimensional growth we demonstrate the agreement of the cell population kinetics in two and three dimensions.

References:
[1] M. Block, E. Schöll, and D. Drasdo, Phys. Rev. Lett. (accepted) 2007.
[2] A. Brú, S. Albertos, J. L. Subiza, J. L. García-Asenjo, and I. Brú, Biophys. J. 85, 2948 (2003).