Berlin 2008 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 11: Transport Processes
BP 11.4: Vortrag
Dienstag, 26. Februar 2008, 16:00–16:15, C 243
Stochastic models for bidirectional transport on biological networks — •Maximilian Ebbinghaus1, Rosemary Harris2, and Ludger Santen1 — 1Department of Theoretical Physics, Saarland University, 66041 Saarbruecken, Germany — 2School of Mathematical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
The intracellular transport on the cytosceletal filament network is driven by molecular motors. They carry different kinds of cargo through the cell by performing a directed stochastic along the polarized filaments. Although the motion of a given molecular motor is unidirectional, it is possible to transport cargo in opposite direction along a filament, e.g., dyneins and kinesins move in opposite directions along microtubule filaments. We model the bidirectional transport by means of a one-dimensional stochastic lattice models. The model motor proteins interact by exclusion such that effective transport on a single track is possible only by detaching and reattaching moves from the microtubule. Simulations have been carried to investigate the influence of different hopping rates and densities on mean current, path lengths and cluster sizes on the filament. In addition, the influence of tau proteins that decorate the filament will be presented. These proteins intervene in the system by altering the attachment rate of kinesins only. Thus, spatial disorder is found in the system and the impact on measurable quantities have been studied. The results of these simulations can be used in order to elucidate general transport phenomena in elongated cells as, e.g., axons.