Berlin 2008 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Physics of Cells
BP 17.1: Vortrag
Mittwoch, 27. Februar 2008, 14:00–14:15, PC 203
Collective Dynamics of Endocytic Vesicles in Membrane Trafficking — •Mirko Birbaumer1, Markus Kalisch2, Frank Schweitzer3, Peter Bühlmann2, and Lucas Pelkmans1 — 1Institute of Systems Biology, Swiss Federal Institute of Technology, ETH Hönggerberg, CH-8093 Zurich — 2Seminar for Statistics, Swiss Federal Institute of Technology, Leonhardstrasse 27, CH-8092 Zurich — 3Chair of Systems Design, Swiss Federal Institute of Technology, Kreuzplatz 5, CH-8032 Zurich
Spatial organization and compartmentalization of intracellular organelles such as endocytic vesicles play an essential role for many cellular processes. A variety of different vesicle patterns can result from a systematic perturbation of the cell, as e.g. by RNA interference in mammalian cells. By silencing a large set of genes in a mammalian cell numerous well distinguishable patterns arise and we are therefore dealing with a clustering problem. In order to cluster vesicle patterns, we first need to extract as much relevant information about intracellular organelles as possible, such as intensity distribution, location with respect to the cell center, shape, their spatial distribution and quantity. A new clustering approach enables us to distinguish between different patterns and group these according to their properties. These patterns should also result as steady states from a macroscopic theory of intracellular transport. Here we present a modeling approach of intracellular trafficking based on Brownian Agents.