Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 2: DNA and Chromatin

BP 2.4: Vortrag

Montag, 25. Februar 2008, 11:15–11:30, PC 203

Phase diagram of chromatin within the two angle model for spherical and cylindrical shape of the nucleosomes — •Dieter Heermann and Philipp Diesinger — University of Heidelberg, Institute of Theoretical Physics, Philosophenweg 19, D-69120 Heidelberg

We have studied the phase diagram for chromatin within the framework of the two-angle model. We reveal the fine-structure of the excluded-volume borderline for spherical type nucleosomes and for cylindrical shape nucleosomes. Thus we where able to give a Ramachandran like diagram for the chromatin fiber. Furthermore, we examined how fluctuations in the distribution of the H1 histones or changes of the vertical distance between the in and outgoing DNA strand affect the chromatin fiber and its biophysical properties.