Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 24: Actin Dynamics

BP 24.3: Vortrag

Donnerstag, 28. Februar 2008, 14:45–15:00, C 243

Actin polymerization and ATP hydrolysis kinetics — •Xin Li¹, Jan Kierfeld^1,2, and Reinhard Lipowsky¹ — ¹MPI of Colloids and Interfaces, Science Park Golm, 14424 Potsdam — ²Technische Universität Dortmund, Lehrstuhl für Theoretische Physik I, 44221 Dortmund

Actin polymerization plays an important role in many aspects of cell dynamics. This active process involves the hydrolysis of ATP molecules, which takes place within an ATP-rich cap and can be spatially separated from the assembly process. In this study, we theoretically compare different mechanism for the coupling between ATP hydrolysis and actin polymerization and describe their effects on experimentally observable quantities, such as cap length, total hydrolysis rate, and actin filament growth rate.