Berlin 2008 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 8: POSTERS Dynamics and Diffusion

CPP 8.17: Poster

Montag, 25. Februar 2008, 16:45–19:00, Poster A

A colloidal approach to unspecific protein adsorption of protein films — •Olaf Leidinger, Markus Bellion, and Ludger Santen — Fachrichtung theoretische Physik, Universität des Saarlandes, 66041 Saarbrücken

We investigate the unspecific adsorption of proteins, which are modelled as colloidal particles. The particle-particle interactions are described in the framework of the DLVO theory, which includes steric repulsion, electrostatic and van der Waals interactions. In addition to this, we introduce an internal degree of freedom representing different conformations of the model protein at the surface.

By means of extensive Monte Carlo simulations we reproduce the experimentally observed characteristics of the biofilm formation. The adsorption kinetics can be divided into three intervals: Initially the adsorption is limited by the flux of particles to the surface. In a second interval one observes domain formation of compactified proteins and finally the surface coverage reaches its stationary value. The robustness of this scenario is scrutinized for various model parameters.