Berlin 2008 – wissenschaftliches Programm

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SYSM: Symposium Single Molecules

SYSM 1: Single molecules

SYSM 1.3: Hauptvortrag

Dienstag, 26. Februar 2008, 15:00–15:30, H 0105

Single Molecule Studies on Myosin Motors — •Claudia Veigel — National Institute for Medical Research, Mill Hill, London, UK

Many types of cellular motility are based on the myosin family of motor proteins. There are now known to be at least 18 different classes of myosins, involved in muscle contraction, intracellular transport processes, exocytosis or even signal transduction in vision or hearing. Using a combined approach of recombinant protein expression and single molecule techniques including optical tweezers we study the basic mechanisms of force production and movement of these molecular machines on the single molecule level. In this talk we will report on our recent studies on myosins class V and VI which transport cargo, such as cyplasmic vesicles, processively over micrometer distances along the actin cytoskeleton in the cell.