Regensburg 2010 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 32: Posters: Physics of Cells

BP 32.5: Poster

Donnerstag, 25. März 2010, 17:15–20:00, Poster B1

The contribution of microtubules to the mechanical properties of cells — •Kenechukwu David Nnetu, Tobias Kießling, Roland Stange, Anatol Fritsch, and Josef Käs — University of Leipzig, Institute of Experimental Physics I, Linnéstr. 5, 04103, Leipzig

A cell as a complex system is made up of various subcellular structures that allows it to sense and react to its environment. While alot of studies on the mechanical properties of cells have been done with adherent cells, little is known about the behaviour of cells in suspension. Although the state of suspension is not the most physiological, cells do sometimes find themselves in suspension for example during cancer metastasis as they move to other parts of the body through the blood and lymph vessels . Using the microfluidic optical stretcher that probes the mechanical properties of cells in suspension we studied the effect of the drugs Taxol and Latrunculin A. This allows a deeper insight into the contribution of microtubules to cellular mechanics.