DPG Phi
Verhandlungen
Verhandlungen
DPG

Regensburg 2010 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Downloads | Hilfe

CPP: Fachverband Chemische Physik und Polymerphysik

CPP 45: Focus: Charge Effects in Soft and Biological Matter I (jointly with BP)

CPP 45.4: Vortrag

Donnerstag, 25. März 2010, 12:15–12:30, H45

DNA Translocation through Nanopores: What is the role of dielectric permittivity? — •Stefan Kesselheim1, Marcello Sega2, Mehmet Süzen3, and Christian Holm11Institut für Computerphysik, Universität Stuttgart — 2Department of Physics and INFN, University of Trento — 3Institute of Photonic Sciences, Castelldefels (Barcelona), Spain

We investigate the free energy barrier of a single DNA molecule filed through a synthetic nanopore. We employ a recently developed algorithm (ICC*) that allows to take into account the dielectric contrast at the membrane/solute interface in coarse-grained molecular dynamics simulations. The investigations show the crucial contribution of dielectric mismatch to the translocation free energy barrier. We show that for low ionic strength and DNA fragments up to 100 bp the dielectric boundary forces dominate over the entropic contribution caused by DNA flexibility.

100% | Mobil-Ansicht | English Version | Kontakt/Impressum/Datenschutz
DPG-Physik > DPG-Verhandlungen > 2010 > Regensburg