Regensburg 2010 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 10: Basic and Applied Medical Physics (Poster Session)
ST 10.3: Poster
Mittwoch, 24. März 2010, 16:00–17:00, H41
Optimized setup for parahydrogen induced polarization by application of hollow fiber membranes — Meike Roth1, Petra Kindervater1, Joachim Bargon2, Hans W. Spiess1, and •Kerstin Münnemann1 — 1Max-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany — 2Institute of Physical and Theoretical Chemistry, University of Bonn, Wegelerstrasse 12, D-53115 Bonn, Germany
Enhancing the sensitivity of nuclear magnetic resonance measurements via Parahydrogen Induced Polarization (PHIP) is of high interest for spectroscopic investigations. In order to achieve the highest possible sensitivity gain it is of great importance to optimize the reaction and measurement conditions of the parahydrogenation technique. We optimized the conversion rate and established optimal NMR measurement conditions by utilizing hollow fiber membranes for continuous parahydrogen delivery while performing PASADENA experiments. This new way of dissolving parahydrogen more efficiently into water without the occurrence of foam and bubbles offers the opportunity to implement continuous flow measurements under pressure, leading to higher conversion rates and higher polarization levels. Furthermore, this careful control of the parahydrogenation reaction generates a constant hyperpolarization of 1H and 13C over a certain time (several minutes) which enables us to perform 2D NMR experiments with very high sensitivity.