Regensburg 2010 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 12: High-LET Radiation Therapy 2
ST 12.5: Vortrag
Donnerstag, 25. März 2010, 12:20–12:40, H41
Distribution of DNA lesions in amorphous track structure — •Thomas Friedrich1, Thilo Elsässer1, Marco Durante1,2, and Michael Scholz1 — 1GSI Helmholtzzentrum für Schwerionenforschung, Planckstraße 1, 64291 Darmstadt — 2Technische Universität Darmstadt, Institut für Festkörperphysik, Hochschulstraße 6-8, 64289 Darmstadt
There is evidence that the effect of radiation to cells is mediated predominantly by lesion induction to the DNA. Whereas for radiation qualities with low linear energy transfer (LET) the dose and therefore the induced lesions can be assumed to be distributed homogeneously over the cell nuclei, in the case of ion irradiation the dose is deposited within a narrow peaked track structure profile around the ion trajectory. In the latest version of the Local Effect Model (LEM), spatial distributions of DNA lesions simulated within an amorphous track structure form the starting point to quantify the enhanced effectiveness of high LET radiation qualities compared to photon radiation. We discuss the implementation into the local effect model and present comparisons of model calculations with experimental data.