Berlin 2012 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 22: Posters I

DY 22.11: Poster

Mittwoch, 28. März 2012, 17:00–19:00, Poster A

Desynchronizing effect of high-frequency stimulation in a generic cortical network model — Markus Schütt and •Jens Christian Claussen — Institut für Neuro- und Bioinformatik, Universität zu Lübeck

Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most marked effects around 100 Hz. We apply superthreshold electrical stimulation, specifically depolarizing DC current, interrupted at different frequencies, to a simple model of a population of cortical neurons which uses phenomenological descriptions of neurons by Izhikevich and synaptic connections on a similar level of sophistication. With this model, we are able to reproduce the optimal desynchronization around 100Hz, as well as to predict the full frequency dependence of the efficiency of desynchronization, and thereby to give a possible explanation for the action mechanism of TCES.

[1] Markus Schütt and Jens Christian Claussen (submitted)