Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 14: Biomaterials and Biopolymers I (joint with CPP)
BP 14.9: Vortrag
Dienstag, 12. März 2013, 12:00–12:15, H34
Structure and Dynamics of Myelin Basic Protein as a Model System for Intrinsically Disordered Proteins — •Andreas Stadler1, Laura Stingaciu2, Aurel Radulescu3, Olaf Holderer3, Clement Blanchet4, Ralf Biehl1, and Dieter Richter1 — 1Forschungszentrum Jülich, JCNS-1/ICS-1, 52425 Jülich, Germany — 2Forschungszentrum Jülich, JCNS, Outstation at the Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA — 3Forschungszentrum Jülich, JCNS, Outstation at FRM II, 85747 Garching, Germany — 4EMBL, Hamburg Unit, EMBL c/o DESY, Notkestrasse 85, Hamburg 22607, Germany
Myelin basic protein (MBP) is a major component of the myelin sheath in the central nervous system. In aqueous solution MBP is primarily unstructured. From a biophysical point of view, the disordered protein can serve as a model system to study the physical properties of disordered or unfolded proteins.
Neutron and X-ray scattering experiments were performed on the protein in solution. Small angle scattering and neutron spin-echo spectroscopy allowed us to gain quantitative information on the structural and the dynamical properties of MBP. The results of these experiments will be presented and compared to different models of polymer theory.