Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Biomaterials and Biopolymers II (joint with CPP)

BP 17.4: Vortrag

Mittwoch, 13. März 2013, 10:30–10:45, H43

Biocompatibility of Fe-Pd ferromagnetic shape memory alloys - influence of surface roughness and protein coatings — •Uta Allenstein^1,2,3, Yanhong Ma², Ariyan Arabi-Hashemi², Stefan G. Mayr^2,3,4, and Mareike Zink¹ — ¹Division of Soft Matter Physics, Institute for Experimental Physics I, University of Leipzig — ²Leibniz-Institute for Surface Modifications (IOM) — ³Translational Center for Regenerative Medicine (TRM), University of Leipzig — ⁴Faculty of Physics and Earth Sciences, University of Leipzig

Recent decades have seen a huge turn in implantology and biomaterial development towards regenerative medicine. The approach in orthopedic surgery is no longer to just replace damaged tissue by a passive implant that evokes the least possible interference with biological tissue, but rather to provide active stimulation and actuation. Fe-Pd ferromagnetic shape memory alloys are a promising new class of smart materials with a unique set of properties ideal for biomedical applications, including superelasticity, magnetically switchable strains and biocompatibility. In this study the latter was shown by in vitro experiments with NIH 3T3 fibroblasts, MCF 10A epithelial cells and HOB osteoblasts on vapor-deposited single crystalline Fe₇₀Pd₃₀ thin films and roughness graded polycrystalline splat-quenched samples. Proliferation, adhesion and morphology were assessed on substrates of different surface roughness and different adhesive coatings, such as fibronectin, laminin and poly-L-lysine, as well as RGD peptides.