Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 20: Statistical Physics in Biological Systems II (joint with DY)
BP 20.3: Vortrag
Mittwoch, 13. März 2013, 15:45–16:00, H43
Monte Carlo simulation of the patterns of histone acetylation in response to MS-275 — •Davoud Pouladsaz1 and Azadeh Ebrahimi2 — 1Department of Biological Physics, Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2Department of Neuropathology, Faculty of Medicine, University of Tübingen, Tübingen, Germany
Abnormal activities of histone decaetylases (HDACs) are considered to be associated with various neurological disorders, from oncogenesis, to neurodegenerative and psychiatric disorders. In this scheme, HDACs are potential targets for therapeutic development. HDAC inhibition has been reported in several studies to improve cognitive function and increase neural longevity. A novel HDAC inhibitor is MS-275, a benzamide derivative with in vivo antitumor activity and selectivity against HDAC1 and HDAC3. We perform computer simulations based on Monte Carlo method in order to describe the patterns of histone acetylation in the brain in response to MS-275. According to previous experimental results, MS-275 is a potent brain region-selective HDAC inhibitor. We theoretically produce similar acetylation profiles associated with the measurements in different regions of the brain, and calculate the changes in the acetylation by means of stochastic processes representing the inhibition of HDACs. The theoretical results show significant correlation to experimental measurements.