Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 24: Posters: Physics of Cells

BP 24.20: Poster

Mittwoch, 13. März 2013, 17:30–19:30, Poster C

Persistent motion in the crowd - The role of superdiffusivity in cell colony dynamics — •Patrick Krauss, Janina Lange, Claus Metzner, and Ben Fabry — Department of Physics, Biophysics Group, Friedrich-Alexander University, Erlangen, Germany

We study the 3D growth dynamics of circular tumor colonies on planar substrates. By tracking the motion of single cells within dense colonies, cell trajectories were found to have a surprisingly high degree of directional persistence, with a mean squared displacement (MSD) increasing as a fractional power of lagtime. The fractional exponent of the MSD, as well as the distribution of migration directions, depend systematically on the radial position within the colony. This is a qualitative difference to liquid spreading models of tumor growth, were the particles search for a global low energy configuration by non-directional diffusion. Using a generalized Molecular Dynamics method, we study the relation between directional persistence, cell-cell- and cell-surface-interactions, cell proliferation, and the resulting 3D morphology of the colony. Results are compared to experimental data from different cell lines.