Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 5: Cytoskeleton
BP 5.5: Vortrag
Montag, 11. März 2013, 16:15–16:30, H43
Mechanochemical patterning of the PAR system in C. elegans — •Vijay Krishnamurthy1,2, Justin Bois3, Frank Jülicher1, and Stephan Grill1,2 — 1Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany. — 2Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Straße 108, 01307 Dresden, Germany. — 3UCLA Department of Chemistry and Biochemistry, Los Angeles, CA 90095, USA.
The polarization of partitioning defective (PAR) proteins into anterior and posterior domains is a conserved mechanism in the zygotes of Caenorhabditis elegans. This segregation is driven by flows established in the actomyosin cortex. Passive advection of the PARs by these flows is known to lead a transient segregation of the PAR system. However, the mechanism by which the PAR proteins regulate the cortical flows is unclear. We present a model which incorporates the feedback of the PAR concentration fields into cortical flows, via a coupling to the local myosin concentration. This leads to stable segregated states of the PAR system. Our model provides a self-consistent and closed mechanism for the polarization of the PAR-actomyosin system which compares well with the known experimental facts.