Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 7: Symposium Magnetic Nanoparticles in Biomedical Diagnostics and Therapy (SYBD, joint with MA, CPP and ST)

BP 7.1: Hauptvortrag

Montag, 11. März 2013, 15:00–15:30, H1

Functionalization and Pharmaceutical Aspects of Magnetic Nanoparticles (Magnetic Carriers) — •Urs O. Häfeli — University of British Columbia, Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada

This presentation will review the properties and applications of modern magnetic nanoparticles and microspheres for application as nanomedical agents, both for diagnosis and therapy of different diseases. Basic applications in biomedicine and industry, clinical applications, as well as open questions regarding risk and economy will be discussed.

Important features make nanoparticles and microspheres interesting for in vitro and in vivo applications: biocompatibility, biodegradability, transport capacity, surface functionalization with biological active molecules, binding of fluorescent and radioactive markers, increasing surface area with decreasing size, organ-specific targeting.

To further increase the particles efficiency, further work is necessary in the design of effective magnetic targeting systems, the coatings for optimized particles, the choice of targeting ligands, as well as the maximization of the particles* magnetic moment. Altogether, exciting in vivo applications are possible in magnetic guidance and controlled delivery of drugs, genetic material, and stem cells, in addition to their current use for the contrast enhancement in magnet resonance imaging and local hyperthermia treatment of cancer.

For additional information about the scientific field of magnetic particles, please check out www.magneticmicrosphere.com.