DPG Phi
Verhandlungen
Verhandlungen
DPG

Regensburg 2013 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

DY: Fachverband Dynamik und Statistische Physik

DY 9: Poster I: Statistical Physics in Biological Systems (joint with BP)

DY 9.14: Poster

Montag, 11. März 2013, 17:30–19:30, Poster B2

Hybrid simulation model for spatiotemporal intracellular calcium signals — •Martin Rückl1, Nagaiah Chamakuri2, and Sten Rüdiger11Humboldt-Universität, Berlin — 2RICAM, Linz, Austria

Calcium induced calcium release (CICR) from IP3R channels on the ER membrane and the interplay with calcium buffers can result in complex spatiotemporal calcium distributions in the cytosol which play an important role in intra- and extracellular signaling.

To model those patterns, we solve the coupled reaction diffusion and master equations for both the DeYoung-Keizer [1] and the four state [2] stochastic IP3R gating models, using an interplay between a 3D finite element method and the Gillespie algorithm. We investigate the impact of the local calcium decay after a channel closing and the diffusive coupling of clustered channels on the collective stochastic behaviour of the channels. To obtain different calcium decays we performed simulations for different buffer configurations while the diffusive coupling is altered by means of a larger inter channel distance within a channel cluster. Our results can also be used to assess the reliability of different computationally cheaper approximations frequently used in other works.

[1] D.W. DeYoung and J. Keizer, Proc. Natl. Acad. Sci. U.S.A 89, 9895 (1992).

[2] G. Ullah, I. Parker, D.D. Mak, J.E. Pearson, Cell Calcium, 52(2):152-160, 2012

100% | Mobil-Ansicht | English Version | Kontakt/Impressum/Datenschutz
DPG-Physik > DPG-Verhandlungen > 2013 > Regensburg