Regensburg 2013 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 4: Advances in MR Imaging I
ST 4.2: Vortrag
Donnerstag, 14. März 2013, 09:50–10:10, H41
MR Microscopy of Human Skin Using Phased-Array of Microcoils at 9.4 T — •Katharina Göbel1, Oliver G. Gruschke2, Jochen Leupold1, Pierre LeVan1, Johannes S. Kern3, Jan G. Korvink2,4, Jürgen Hennig1, Dominik von Elverfeldt1, and Nicoleta Baxan1,5 — 1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Germany — 2Lab. of Simulation, University of Freiburg - IMTEK, Germany — 3Dept. of Dermatology, University Medical Center Freiburg, Germany — 4Freiburg Institute for Advanced Studies, University of Freiburg, Germany — 5Bruker BioSpin MRI GmbH, Ettlingen, Germany
MRI of the skin as non-invasive alternative to histopathology requires dedicated approaches to overcome both the low sensitivity and low contrast of standard MR investigations applied at microscale. The geometry of the skin with layers of large lateral dimensions and a few µm thickness demands exceptionally high resolution combined with large imaging matrix size. A home-made microcoil-based MR detector in planar phased-array geometry (diameter = 5.5 mm) was developed to alleviate such limitations by combining the advantages of a large field-of-view and high signal-to-noise ratio. The detector was first characterized in terms of influence on B0 homogeneity and SNR. Trials on healthy and Acne inversa diseased human skin biopsies allowed the acquisition of high resolution images (30×30×100 µm3) in reasonable scan time. Histology was subsequently performed to validate the MRI results, demonstrating the suitability of this methodological approach for the characterization and early detection of structural skin changes.