Berlin 2015 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 43: P8: Nanoparticles and Compsite Materials
CPP 43.12: Poster
Mittwoch, 18. März 2015, 10:00–13:00, Poster A
Drug Carriers based on HPMA Nanoparticles: Molar Mass and Buffer Type — •Bart-Jan Niebuur1, Natalya Vishnevetskaya1, Ekaterina Lomkova2, Petr Chytil2, Sergey Filippov2, and Christine M. Papadakis1 — 1Fachgebiet Physik weicher Materie, Physik-Department TU München, Garching — 2Institute of Macromolecular Chemistry, Prague, Czech Republic
A promising way to achieve site-specifc delivery of anticancer agents is using the enhanced permeation and retention (EPR) effect of N-(2-hydroxypropyl) methacry-lamide (HPMA) nanoparticles containing the drug doxorubicin (Dox) [1]. The present research in this field focuses on exploration of the particle structure and tuning of their properties. Recently, addition of different types of cholesterol and degradation of the linkage is used to tune the size and stability of these nanoparticles in dependence on pH [1].
The aim of the present study is to investigate the influence of molar mass of the HPMA backbone. Using fluorescence correlation spectroscopy (FCS), the size of the nanoparticles with and without Dox as well as the critical micelle concentration (CMC) are determined in a phosphate buffer. Investigation of the polymers containing Dox is challenging because of its broad own fluorescence emission. Moreover, more realistic environments are investigated. For instance, the conditions inside the bloodstream can be mimicked using serum.
[1] Filippov, K. et al., Biomacromolecules 14, 4061 (2013).