Dresden 2017 – wissenschaftliches Programm
CPP 33.8: Vortrag
Mittwoch, 22. März 2017, 11:45–12:00, POT 81
Organic Light-Emitting Diodes for Optogenetic Stimulation of Neurons in Drosophila Larvae — •Caroline Murawski1, Andrew Morton1, Ifor D. W. Samuel1, Stefan R. Pulver2, and Malte C. Gather1 — 1Organic Semiconductor Centre, SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews KY16 9SS, UK — 2School of Psychology and Neuroscience, University of St Andrews, St Mary’s Quad, South Street, St Andrews KY16 9JP, UK
Optogenetics is an emerging method in biology that enables controlling neurons non-invasively with light. Currently, however, only a small number of neurons can be controlled individually so that stimulation of neurons with light still lacks precision compared to the complexity of the brain. To overcome these limitations, we use organic light-emitting diodes (OLEDs), which enable unprecedented high-resolution optogenetic control of thousands of neurons at once. One of the challenges involves the need for very high light intensities (on the order of mW/mm2), a brightness at which OLED efficiency typically decreases dramatically. In this contribution, we show our recent development towards achieving higher brightness OLEDs employing doped charge transport layers. Using these light sources, we demonstrate optogenetic stimulation of neurons in Drosophila (fruit fly) larvae and investigate subsequent behavioral changes at different light intensities.1
 A. Morton, C. Murawski, S. R. Pulver, M. C. Gather, Sci. Rep. 2016, 6, 31117.