Dresden 2017 – wissenschaftliches Programm

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MM: Fachverband Metall- und Materialphysik

MM 11: Biomaterials

MM 11.1: Vortrag

Montag, 20. März 2017, 11:45–12:00, IFW D

Macromolecular HPMA-based drug delivery system - behavior in protein environment — •Xiaohan Zhang1, Bart-Jan Niebuur1, Petr Chytil2, Tomas Etrych2, Sergey K. Filippov2, Alexey Kikhney3, Florian Wieland3, Dmitri I. Svergun3, and Christine M. Papadakis11Technische Universität München, Physik-Department, Fachgebiet Physik weicher Materie, Garching, Germany — 2Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic — 3European Molecular Biology Laboratory, DESY, Hamburg, Germany

Copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) having cholesterol side groups self-assemble into ellipsoidal nanoparticles (NPs) in aqueous solutions [1,2]. The core and the shell are formed by cholesterol and by HPMA, respectively. They have been proposed as drug carriers. However, little is known on their behavior in human blood environment.

We use synchrotron small-angle X-ray scattering (SAXS) to investigate HPMA copolymers in an aqueous solution of human serum albumin(HSA), which is very abundant in human blood, to investigate the influence of HSA on the NPs' structure. The length of the NPs is reduced even if very small amounts of HSA are present. We speculate that HSA binds to cholesterol groups and removes them from the NPs.

[1] S. K. Filippov, et al., Biomacromolecules, 2012, 13, 2594

[2] S. K. Filippov, et al., Biomacromolecules, 2013, 14, 4061

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