Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 10: Postersession II
BP 10.11: Poster
Montag, 12. März 2018, 17:30–19:30, Poster C
Cytoskeletal morphology of oral keratinocytes and oral carcinoma cells — •Nina Bartels1, Maja Strugacevac1, Niklas Ullrich1, Julia Kristin2, Constanze Wiek2, Jörg Schipper2, and Mathias Getzlaff1 — 1Institute of Applied Physics, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany — 2Department of Otorhinolaryngology, Düsseldorf University Hospital, Moorenstrasse 5, 40225 Dusseldorf, Germany
Our group is investigating the differences in cell morphology and physical properties of head and neck squamous cell carcinoma cells (HNSCC) and oral keratinocytes. As the cytoskeleton plays an important role in elasticity and mechanical properties of the cell, it is a significant part of our research. The cell lines, originating from different locations of the oral mucosa are investigated using a confocal laser scanning fluorescence microscope. To obtain more information about the cell morphology with a focus on the cytoskeleton, the cells were stained using SiR-Actin (actin filaments) and SiR-Tubulin (microtubules) staining kits. Three-dimensional images of the cells were used to compare the cytoskeleton of the different cell lines in size, volume and shape. The cytoskeleton of cell lines originating from the same area show similar properties whereas cell lines from other head and neck areas show differences. Our latest results will be presented and discussed.