Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 10: Postersession II
BP 10.18: Poster
Montag, 12. März 2018, 17:30–19:30, Poster C
Flow of a cell inside a microfluidic channel using FEM simulation — •Ralf Schuster1, Tobias Neckernuss1, Daniel Geiger1, Ulrich Simon2, Kay-Eberhard Gottschalk1, and Othmar Marti1 — 1Institute of Experimental Physics, Ulm University, D-89081 Ulm — 2Ulmer Zentrum für Wissenschaftliches Rechnen (UZWR), Ulm University, D-89081 Ulm
From the mechanical deformation of cells conclusions, regarding type, state, size or some inherent feature, can be drawn. Variations of structure and shape of cells play an important role for cell migration and proliferation. For instance tumor and normal cells can be distinguished by elasticity, indicated by the amount of deformation under a given stress. Metastasizing cancer cells can have a softer cytoskeleton through changes in the network, leading to a reduced drag resistance when passing through narrow constrictions.
The parabolic flow profile inside a microfluidic channel causes the cells to deform, while passing through it. The deviation from circularity of the cell at steady-state conditions can be taken as a characteristic measure for the deformation (Otto et al. Nature Methods 2015). Two different finite element-modeling approaches will be shown. The composition and the values of the properties of the cell are generated according to other works and experiments, performed at our Institute. Achieving accordance between experiment and simulation will lead to numerical values for the material parameters of cells respectively cell types and will be the basis for further experiments.