Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.33: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Cortical Actin Contractility of Single Suspended Cells — •Enrico Warmt, Steffen Grosser, Erik Morawetz, and Josef Käs — Universität Leipzig, Soft Matter Physics Division, Linnéstr. 5, 04103 Leipzig

Up to now cellular contractility was seen basically as a force dipole requiring adhesion sites and actin stress fibers, mainly necessary during cell migration. In this study, we investigate suspended cells regarding active contractility, lacking stress fibers and adhesion points. Epithelial cells assemble a strong acto-myosin cortex providing pretension forming round cell shape, and exhibiting more contractile behavior during long optical stretcher observation. In contrast, mesenchymal cells, show more elongated cell shapes and less cortical contractility. Cell contractility needs a short mechanical impulse to induce acto-myosin contraction of the cell cortex, even below initial cell elongation. We will focus on how these findings correlate to different migratory and jamming behavior in healthy and mesenchymal cell clusters.