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BP: Fachverband Biologische Physik

BP 10: Postersession II

BP 10.49: Poster

Montag, 12. März 2018, 17:30–19:30, Poster C

Cellular Potts Models for Neural Tissue Simulations — •Jakob Rosenbauer and Alexander Schug — Forschungszentrum Jülich, 52428 Jülich, Germany

Experimental capability in biology has been leaping forward in the last decades. Methods such as light-sheet microscopy have given more and more insights into the dynamics of tissue. Computational models are of rising importance for biological questions. The cellular Potts model (cpm) is a computational model derived from the Potts model. The development of tissue can be modelled with single cell resolution, up to a very high number of cells. A parallel version was developed, facilitating large three dimensional simulations of tissue dynamics on large cluster networks, which can be applied to a large variety of biological questions. Through a high scalability this model allows for modelling of much larger specimen than possible to date. The patterning of the neural plate in zebrafish embryonal development was modelled using the parallel cpm. The tissue dynamics during epiboly were modelled by the cpm. In that developmental stage the neural plate starts its patterning into different regions via a signalling molecule. Different modes of transport of that molecule, diffusion and so called cytonemes, were compared.