Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 15: Postersession III
BP 15.52: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster B
Combination of Monte-Carlo simulations and experimental results to determine the microscopic energy depoit at DNA — •Marc Benjamin Hahn1,2, Tihomir Solomun2, and Heinz Sturm2,3 — 1Freie Universität Berlin — 2Bundesanstalt für Materialforschung — 3Technische Universität Berlin
The quantification of radiation induced damage to DNA in aqueous environment is of fundamental interest for dosimetry and its application in radiation-therapy and protection. We present a combined experimental and simulational approach to quantify and compare radiation induced damage to biomolecules in liquid environment for a wide range of primary radiation sources e. g. photons, electrons or ions and targets, such as DNA, proteins or cells.[1] To show its viability, we will apply this method to an experimentally challenging systems, the direct irradiation of plasmid DNA (pUC19) in water with electrons as primary particles. Here we combine Geant4 electron-scattering simulations with calculations concerning the diffusion and convection induced movement of the biomolecules, within a coarse-grained model of the irradiated liquid. Additionally a microscopic target model for the plasmid DNA based on the relation of lineal energy and radiation quality is used to calculate the effective target volume.
[1] Hahn at al. Phys. Rev. E 95 052419 (2017)