Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 15: Postersession III
BP 15.68: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster B
Computational Simulation of Tissue Engineered Heart Repair — •Moritz Kalhöfer-Köchling1, Yong Wang1, Martin Uecker2, Jens Frahm3, Wolfram Zimmermann2, and Eberhard Bodenschatz1 — 1MPI for Dynamics and Self-Organization, 37077 Göttingen, Germany — 2University Medical Center Göttingen, 37075 Göttingen, Germany — 3MPI for Biophysical Chemistry, 37077 Göttingen, Germany
Myocardial infarction is the leading cause of death globally. Remuscularization of the heart using engineered heart muscle (EHM) tissues is a promising technique for damage repair, not only supporting scarred tissue passively, but also contracting in unison with the surrounding healthy tissue. Thereby, in the best of cases, it might reconstitute normal cardiac function. To date, the affect of EHM implants on the elastic properties and thus on the cardiac pump functions are not well understood. Computational simulation provides virtual medical diagnosis and prospective output of surgery. Employing the Holzapfel-Ogden constitutive law together with patient MRI and pressure data, we developed a heart model and strive to find corresponding EHM qualities for an optimal cure of the patient. This work was supported by the Max Planck Society and the German Center for Cardiovascular Research, and was conducted within the Physics to Medicine Initiative at Goettingen Campus between MPG and UMG.