Berlin 2018 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 20: Poster Session I
CPP 20.6: Poster
Montag, 12. März 2018, 17:30–19:30, Poster A
Protein exchange on Gold Nanoparticles -- Tailored Polymers as model systems — •Carmen Radeke1,2, Jonas Schubert1,3, Munish Chanana4,5, and Andreas Fery1,3 — 1Department of Nanostructured Materials, Leibniz-Institut für Polymerforschung Dresden e. V. — 2Department of Biopolymers, University of Bayreuth, 95440 Bayreuth, Germany — 3Physical Chemistry of Polymer Materials, Technische Universität Dresden, D-01062 Dresden, Germany — 4Institute of Building Materials (IfB), ETH Zurich, 8093 Zurich, Switzerland — 5EMPA Dübendorf, 8600, Dübendorf, Switzerland.
Understanding the behavior of NPs in biological systems is one of the major challenges on the way to new therapeutics and diagnosis tools in medicine. Therein, the generation of an undefined protein corona is a crucial point, as by this, the physicochemical properties of the NPs and therefore also their behavior change drastically. To address these problems, we used a defined protein corona on Au NP as model system. This has the advantage that a fluorescent labeled protein shell can be detected when being exchanged. To understand the influence of physicochemical parameters (e.g. molecular weight, functional groups and concentration of free protein) of protein exchange under physiological conditions, we simplified the system by using polymer and polypeptides as model systems.