Erlangen 2018 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
MO: Fachverband Molekülphysik
MO 22: Posters 3: Experimental and Theoretical Techniques and High Resolution Spectroscopy
MO 22.11: Poster
Donnerstag, 8. März 2018, 16:15–18:15, Zelt West
Fragmentation pathways of protonated nucleic acid building blocks — •Martin Pitzer1,2, Christian Ozga1, Catmarna Küstner-Wetekam1, Philipp Reiß1, Alexandre Giuliani3, and Laurent Nahon3 — 1Institut für Physik und CiNSAT, Universität Kassel, Germany — 2Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel — 3Synchrotron SOLEIL, Gif-sur-Yvette, France
Ultraviolet radiation is known to have large absorption cross sections in biologically relevant molecules. Due to the complexity of these molecules, many destructive and non-destructive pathways for deexcitation exist. Which pathways are chosen is extremely relevant for the resulting radiation damage in biological tissue. Although not performed in a natural environment, experimental studies on isolated molecules are essential to understand the interplay between photoexcitation and fragmentation.
By combining an Electrospray Ionization source (ESI) with tunable photoexcitation in the VUV range and a tandem mass spectrometer, the appearance energies of fragments can be determined in dependence of various parameters such as hydration or charge state [1]. Our contribution shows recent results for the RNA components uracil and uridine which exhibit a rich fragmentation behaviour in the region of 4-12 eV photon energy. We compare for various fragments how the yield depends on the exciting photon energy and are thus able to test theoretically predicted fragmentation pathways and dissociation thresholds.
[1] A. Milosavljevic et al., J. Synchrotron Rad. 19, 174-178 (2012)