Dresden 2020 – wissenschaftliches Programm
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BP 10.26: Poster
Montag, 16. März 2020, 17:30–19:30, P2/3OG
A dynamic model for proteome partitioning — •Anne-Lena Moor, Kalok Kam, and Stefan Klumpp — Institut für Dynamik komplexer Systeme Georg-August-Universität Göttingen
To reproduce as efficiently as possible, bacteria adapt their proteome and metabolism to different environments with different nutrient availability. A key ingredient of this adaptation is the regulation of the fraction of ribosomes in the proteome, which is subject to simple growth laws. In this work, the growth laws are used to analyze the dynamics of cell growth and proteome adaptation, specifically how the ratio of ribosomes to metabolic proteins is modulated to achieve the maximal growth rate. A model is presented that describes the dynamics of this regulation.