Dresden 2020 – wissenschaftliches Programm
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BP 10.5: Poster
Montag, 16. März 2020, 17:30–19:30, P2/3OG
Characterization of an ultrasonic transmitter for mechanical manipulation of cancer cells in vitro — •Simon Sommerhage1, Hsiao-Ching Tsai1, Monika Illenseer1, Paul Dunst2, Tobias Hemsel2, and Mathias Getzlaff1 — 1Institute of Applied Physics, Heinrich Heine University Düsseldorf — 2Dynamics and Mechatronics, Paderborn University
Ultrasound is a well-established medical application for diagnostic and therapeutic purposes (e.g. HIFU). In this study the effect of unfocused ultrasound with lower intensities compared to HIFU on human oral squamous cancer cells (UD-SSC-1) was investigated. Recent studies have shown that cancer cells exhibit a significantly lower Young’s modulus than their healthy counterparts. This should cause a different response to external mechanical stimuli by ultrasound. According to recent study’s theoretical analysis the frequency-response of a cell should show a resonance-like characteristic with a peak frequency lying within the range 104-106 Hz. To be able to test this hypothesis, the electrodynamical properties of an ultrasonic transmitter must be characterized. Therefore, the vibration velocity depending on the adjusted electrical current was measured using a laser Doppler vibrometer (Polytec LSV 60). This was done for different resonance frequencies yielding two suitable resonance modes at about 24 and 67 kHz. The UD-SCC-1 cells were irradiated and observed with an inverted light-microscope in vitro. At constant distance and vibration velocity the qualitative effect was higher for the 67 kHz than for the 24 kHz mode. These results may be a proof of principle for the cell-resonance hypothesis.