Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Poster VI

BP 18.11: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/2OG

Flow reorganisation in the brain microvasculature during a stroke — •Agnese Codutti1 and Karen Alim1,21Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany — 2Physik-Department, Technische Universität München, Garching, Germany

Ischemic brain strokes are a major concern for public health. Major strokes obstructing main arteries cause reorganisation of flows through- out the microvasculature, likely with a long lasting influence on brain microvasculature behaviour and topology. Strikingly flow reorganisa- tion is different in different parts of the brain vasculature. While the loopy surface arteriole network undergoes stops and reversals during a stroke, the penetrating arterioles exhibit steady flow direction. One hy- pothesis is that the flow reorganisation at the surface prevents changes in the penetrating arterioles. Here, we investigate if network topology and hierarchy of the system drives penetrating arterioles to be robust asking: Is the network designed to be resilient to such changes? To test this hypothesis, we analytically solved the flows in a toy model of an H- shaped network module showing that flow reversal in the penetrating arterioles can happen in principle for great pressure instabilities, due to the hierarchy and topology of the network. In two dimensional irreg- ular networks optimised for transport, the pressure difference needed for the reversal yet is even higher, supporting the hypothesis of the in-built resilience of the network. Currently, we are testing the de- pendence on different network properties to identify the main factor inducing the resilient behaviour.

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